Dr. Schilsky earned his M.D. at the University of Chicago Pritzker School of Medicine. Following a residency in internal medicine at the University of Texas Southwestern Medical Center and Parkland Memorial Hospital in Dallas, he received training in medical oncology and clinical pharmacology at the National Cancer Institute (NCI). He then served as assistant professor of medicine at the University of Missouri-Columbia School of Medicine before returning to the University of Chicago where he served in a number of roles including as professor of medicine, director of the University of Chicago Cancer Research Center, associate dean for clinical research, and chief of the section of hematology-oncology. He also served as chair of the Cancer and Leukemia Group B, an NCI-sponsored national cancer clinical trials group.
An international expert in gastrointestinal malignancies and cancer pharmacology, Dr. Schilsky has served on a number of NCI peer review and advisory committees, including as a member and chair of the board of scientific advisors and as a member of the clinical and translational research advisory committee. He served as a member and chair of the oncologic drugs advisory committee of the U.S. Food and Drug Administration, and was president of the American Society of Clinical Oncology where he also served as a board member and a member of board of the Conquer Cancer Foundation.